HMG-CoA reductase
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
HMGR; HMGCoA reductase; HMG CoA reductase; HMGCR; HMGCR (gene); 3-hydroxy-3-methyl-glutaryl-CoA reductase; 3-Hydroxy-3-methylglutaryl-coenzyme A reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent, ) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonic acid, a necessary step in the biosynthesis of cholesterol.